DSP-6952 hydrobromide( DSP6952 | Minesapride )

Catalog No. M10627 CAS No. 1184661-33-3

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HNMR

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Product Name

DSP-6952 hydrobromide
Note

Research use only, not for human use.
Brief Description

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.
Description

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c; enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56 mg/kg; rapidly increases fecal wet weight without increasing fluid content in mice (1-10 mg/kg, p.o.).
In Vitro

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In Vivo

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Synonyms

DSP6952 | Minesapride
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

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Indication

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CAS Number

1184661-33-3
Formula Weight

535.864
Molecular Formula

C21H32BrClN4O5
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)C3=CC(Cl)=C(N)C=C3OC.[H]Br.[H]O[H].[H]O[H]
Chemical Name

(S)-4-amino-5-chloro-N-((4-((1-(2-hydroxyacetyl)piperidin-4-yl)methyl)morpholin-2-yl)methyl)-2-methoxybenzamide hydrobromide

1. Mine Y, et al. Eur J Pharmacol. 2018 Feb 9;826:123-132. 2. Tsubouchi T, et al. Eur J Pharmacol. 2018 Mar 1;826:96-105.

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