DSP-6952 hydrobromide

CAS No. 1184661-33-3

DSP-6952 hydrobromide ( DSP6952;Minesapride )

Catalog No. M10627 CAS No. 1184661-33-3

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DSP-6952 hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.
  • Description
    DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c; enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56mg/kg; rapidly increases fecal wet weight without increasing fluid content in mice (1-10mg/kg, p.o.).
  • Synonyms
    DSP6952;Minesapride
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1184661-33-3
  • Formula Weight
    535.86
  • Molecular Formula
    C21H32BrClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)C3=CC(Cl)=C(N)C=C3OC.[H]Br.[H]O[H].[H]O[H]
  • Chemical Name
    (S)-4-amino-5-chloro-N-((4-((1-(2-hydroxyacetyl)piperidin-4-yl)methyl)morpholin-2-yl)methyl)-2-methoxybenzamide hydrobromide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mine Y, et al. Eur J Pharmacol. 2018 Feb 9;826:123-132.
2. Tsubouchi T, et al. Eur J Pharmacol. 2018 Mar 1;826:96-105.
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