DSP-6952 hydrobromide

Research use only, not for human use.

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c; enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56mg/kg; rapidly increases fecal wet weight without increasing fluid content in mice (1-10mg/kg, p.o.).

DSP6952;Minesapride

Endocrinology/Hormones

5-HT Receptor

5-HT Receptor

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1184661-33-3

535.86

C21H32BrClN4O5

>98% (HPLC)

——

O=C(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)C3=CC(Cl)=C(N)C=C3OC.[H]Br.[H]O[H].[H]O[H]

(S)-4-amino-5-chloro-N-((4-((1-(2-hydroxyacetyl)piperidin-4-yl)methyl)morpholin-2-yl)methyl)-2-methoxybenzamide hydrobromide

(-20℃)

With Ice Pack

≥ 2 years